Phenotype of Gc-globulin influences the macrophage activating factor (MAF) levels in serum

  • Debruyne E
  • Speeckaert M
  • Weygaerde Y
 et al. 
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BACKGROUND: Gc-globulin is a polymorphic protein with three phenotypes: Gc 1-1, Gc 2-1 and Gc 2-2. Deglycosylation of Gc-globulin results in a Gc-macrophage activating factor (Gc-MAF). This study investigated the potential of MAF as a tumour marker and the influence of Gc-phenotypes on serum MAF-concentrations.

METHODS: Gc-phenotype of 98 healthy individuals and 60 cancer patients was determined. MAF-levels of healthy individuals and cancer patients were analysed according to their Gc-phenotype using a Helix pomatia agglutinin-based ELISA. ROC curves analysed the efficiency of MAF as a tumour marker.

RESULTS: MAF-levels between controls and patients were significantly different (p
CONCLUSIONS: Gc-phenotype is a confounding factor when interpreting MAF-data. The value of MAF as a tumour marker varies according to phenotype. Future studies on MAF will have to consider the effect of Gc-phenotype.

Author-supplied keywords

  • Gc-MAF
  • Gc-globulin
  • Helix pomatia agglutinin
  • Lectin-based ELISA
  • Phenotype
  • Tumour marker

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