Phospho-ΔNp63α is a key regulator of the cisplatin-induced microRNAome in cancer cells

  • Huang Y
  • Chuang A
  • Hao H
 et al. 
  • 36


    Mendeley users who have this article in their library.
  • 71


    Citations of this article.


Head and neck squamous cell carcinoma (HNSCC) cells exposed to cisplatin (CIS) displayed a dramatic ATM-dependent phosphorylation of ΔNp63α that leads to the transcriptional regulation of downstream mRNAs. Here, we report that phospho (p)-ΔNp63α transcriptionally deregulates miRNA expression after CIS treatment. Several p-ΔNp63α-dependent microRNA species (miRNAs) were deregulated in HNSCC cells upon CIS exposure, including miR-181a, miR-519a, and miR-374a (downregulated) and miR-630 (upregulated). Deregulation of miRNA expression led to subsequent modulation of mRNA expression of several targets (TP53-S46, HIPK2, ATM, CDKN1A and 1B, CASP3, PARP1 and 2, DDIT1 and 4, BCL2 and BCL2L2, TP73, YES1, and YAP1) that are involved in the apoptotic process. Our data support the notion that miRNAs are critical downstream targets of p-ΔNp63α and mediate key pathways implicated in the response of cancer cells to chemotherapeutic drugs.

Author-supplied keywords

  • DICER1
  • cisplatin
  • microRNA
  • p63
  • squamous cell carcinomas

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Y. Huang

  • A. Chuang

  • H. Hao

  • C. Talbot

  • T. Sen

  • B. Trink

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free