Phosphorothioation of DNA in bacteria by dnd genes

  • Wang L
  • Chen S
  • Xu T
 et al. 
  • 86


    Mendeley users who have this article in their library.
  • 112


    Citations of this article.


Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Lianrong Wang

  • Shi Chen

  • Tiegang Xu

  • Koli Taghizadeh

  • John S. Wishnok

  • Xiufen Zhou

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free