Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers

  • Hamburg N
  • McMackin C
  • Huang A
 et al. 
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OBJECTIVE: Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance. METHODS AND RESULTS: We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and during 5 days of bed rest. Bed rest led to a 67% increase in the insulin response to glucose loading (P

Author-supplied keywords

  • *Insulin Resistance
  • *Motor Activity
  • Adult
  • Bed Rest/*adverse effects
  • Blood Glucose/metabolism
  • Blood Pressure
  • Brachial Artery/physiopathology
  • Case-Control Studies
  • Cholesterol/blood
  • Dyslipidemias/blood/etiology/*physiopathology/ultr
  • Female
  • Forearm/*blood supply
  • Glucose Tolerance Test
  • Humans
  • Hyperemia/blood/*physiopathology/ultrasonography
  • Hypertension/blood/etiology/*physiopathology/ultra
  • Inflammation Mediators/blood
  • Insulin/blood
  • Laser-Doppler Flowmetry
  • Leg/*blood supply
  • Male
  • Microcirculation/physiopathology
  • Reference Values
  • Time Factors
  • Triglycerides/blood
  • Vasodilation

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  • N M Hamburg

  • C J McMackin

  • A L Huang

  • S M Shenouda

  • M E Widlansky

  • E Schulz

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