Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms.

  • Muzumdar R
  • Ma X
  • Yang X
 et al. 
  • 16


    Mendeley users who have this article in their library.
  • 53


    Citations of this article.


Leptin has been shown to decrease glucose-stimulated insulin secretion in both in vivo and in vitro studies. As some of the effects of leptin have been elicited through both peripheral and central mechanisms, we assessed whether leptin modulates insulin secretion also through the central nervous system. We infused leptin or saline through implanted intracerebro-ventricular (ICV) catheters to chronically catheterized, conscious rats (n=15), 2 h after initiation of hyperglycemic (approximately 11 mM) clamp. On ICV administration of leptin, there was a gradual and progressive decrease in plasma insulin levels by 52% with 30 ng (P

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Radhika Muzumdar

  • Xiaohui Ma

  • Xiaoman Yang

  • Gil Atzmon

  • Julia Bernstein

  • George Karkanias

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free