Physiology and consequences of lung hyperinflation in COPD

  • O'Donnell D
  • Laveneziana P
  • 158

    Readers

    Mendeley users who have this article in their library.
  • 86

    Citations

    Citations of this article.

Abstract

Lung hyperinflation commonly accompanies expiratory flow limitation in patients with chronic obstructive pulmonary disease (COPD) and contributes importantly to morbidity and an impoverished quality of life. It is not surprising, therefore, that lung hyperinflation has become an important therapeutic target in symptomatic COPD patients. Acute dynamic increases in lung hyperinflation under conditions of worsening expiratory flow limitation and increased ventilatory demand (or both) can seriously stress cardiopulmonary reserves in patients with more advanced disease. The present understanding of the physiological mechanisms of dynamic hyperinflation during exacerbations of COPD and during physical activity continues to grow, together with an appreciation of its negative mechanical and sensory consequences. In this brief overview, definitions and measurement of lung hyperinflation during rest and exercise will be discussed and its potential clinical importance will be considered. The focus will mainly be on current concepts of the mechanisms of air trapping and its role in inducing respiratory discomfort and activity limitation in COPD.

Author-supplied keywords

  • Chronic obstructive pulmonary disease
  • Dynamic hyperinflation
  • Dyspnoea
  • Exercise
  • Lung volume
  • Respiratory mechanics

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • D. E. O'Donnell

  • P. Laveneziana

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free