Physiology and relevance of human adaptive thermogenesis response

  • Celi F
  • Le T
  • Ni B
  • 60


    Mendeley users who have this article in their library.
  • 16


    Citations of this article.


In homoeothermic organisms, the preservation of core temperature represents a primal function, and its costs in terms of energy expenditure can be considerable. In modern humans, the endogenous thermoregulation mechanisms have been replaced by clothing and environmental control, and the maintenance of thermoneutrality has been successfully achieved by manipulation of the micro- and macroenvironment. The rediscovery of the presence and activity of brown adipose tissue in adult humans has renewed the interest on adaptive thermogenesis (AT) as a means to facilitate weight loss and improve carbohydrate metabolism. The aim of this review is to describe the recent advancements in the study of this function, and to assess the potential and limitations of exploiting AT for environmental/behavioral, and pharmacological interventions.

Author-supplied keywords

  • Adaptive thermogenesis
  • Brown adipose tissue
  • Humans

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Francesco S. Celi

  • Trang N. Le

  • Bin Ni

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free