Placental growth factor and soluble FMS-like tyrosine kinase-1 in early-onset and late-onset preeclampsia

  • Wikström A
  • Larsson A
  • Eriksson U
 et al. 
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OBJECTIVE: To estimate whether alterations in plasma levels of the proangiogenic proteins placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A), and the antiangiogenic protein soluble fms-like tyrosine kinase-1 (sFlt1) were more pronounced in early-onset than in late-onset preeclampsia. METHODS: A cross-sectional study was conducted to estimate the levels of sFlt1, PlGF, and VEGF-A in plasma in a control group of nonpregnant women, in an early control group of women at 24-32 weeks of gestation, in a late control group of women at 36-42 weeks of gestation, and in cases of women with early-onset (before 32 weeks of gestation) and late-onset (after 35 weeks of gestation) preeclampsia. RESULTS: Women with early-onset preeclampsia had a 43 times higher median plasma sFlt1 level than early controls (P

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  • Anna Karin Wikström

  • Anders Larsson

  • Ulf J. Eriksson

  • Peppi Nash

  • Solveig Nordén-Lindeberg

  • Matts Olovsson

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