Plasma (gamma)-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: A pathway associated with myocardial infarction risk?

  • Drogan D
  • Weikert C
  • Dierkes J
 et al. 
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Abstract

Objective-: To investigate the interrelation between plasma (gamma)-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study. Methods and results-: Incident cases of MI were identified among European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam participants without prior MI during 6.0 years of follow-up. Baseline levels of Cys-Gly and oxLDL and GGT activity in plasma were measured in a case-cohort study comprising 837 subjects without incident MI and 116 subjects with incident MI. The relation of GGT, Cys-Gly and oxLDL to MI risk was assessed using Cox proportional hazards regression analysis. After adjustment for established risk factors, hazard ratios associated with a 1-SD unit increase in the log-transformed biomarker were 1.63 (95% CI, 1.30 to 2.05) for GGT, 1.36 (95% CI, 1.07 to 1.72) for Cys-Gly, and 1.37 (95% CI, 1.00 to 1.86) for oxLDL. Cys-Gly and oxLDL accounted for 2.3% of the relation between GGT and MI risk. Conclusion-: The positive association between GGT activity and MI risk appears to be independent of circulating Cys-Gly and oxLDL levels. With Cys-Gly, we found a potential new predictor of MI risk whose impact needs to be further elucidated. (copyright) 2010 American Heart Association, Inc.

Author-supplied keywords

  • adult
  • aged
  • amino acid analysis
  • article
  • cysteinylglycine
  • disease association
  • enzyme activity
  • female
  • gamma glutamyltransferase
  • heart infarction
  • human
  • lipoprotein blood level
  • major clinical study
  • male
  • oxidized low density lipoprotein
  • priority journal
  • risk assessment

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Authors

  • D Drogan

  • C Weikert

  • J Dierkes

  • K Klipstein-Grobusch

  • B Buijsse

  • M Mohlig

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