Plasma YKL-40 in relation to the degree of coronary artery disease in patients with stable ischemic heart disease

  • A.B. M
  • M.J. H
  • E. J
 et al. 
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Background: Inflammation plays a key role in the development of atherosclerosis leading to manifest cardiovascular disease. YKL-40 is a glycoprotein secreted by macrophages and neutrophils in tissues with inflammation. Plasma YKL-40 is increased in patients with acute and chronic coronary artery disease (CAD) and associated with cardiovascular and all-cause mortality in patients with stable CAD. Furthermore, plasma YKL-40 seems to be related to 1, 2 and 3 coronary vessel disease in patients with stable angina pectoris. The aim was to further explore the correlation between YKL-40, High Sensitivity C-Reactive Protein (HsCRP) and different methods for assessments of CAD degree on angiographies. Methods: Plasma YKL-40 and HsCRP levels were determined in samples from 206 consecutive patients with stable angina pectoris admitted for elective coronary angiography (CAG). Plasma YKL-40 in 245 healthy subjects was used for comparison. In addition to one to three vessel stenosis scores, two new scores for evaluating coronary angiographies were invented for discriminating between focal and diffuse CAD and the extent of myocardial ischemia. Results: Plasma YKL-40 levels were increased (p

Author-supplied keywords

  • *cardiology
  • *college
  • *coronary artery disease
  • *ischemic heart disease
  • *patient
  • *plasma
  • C reactive protein
  • angiocardiography
  • angiography
  • atherosclerosis
  • body mass
  • cardiovascular disease
  • chronic obstructive lung disease
  • coronary blood vessel
  • creatinine blood level
  • glycoprotein
  • heart muscle ischemia
  • hypertension
  • inflammation
  • macrophage
  • mortality
  • multivariate analysis
  • neutrophil
  • normal human
  • peripheral occlusive artery disease
  • peripheral vascular disease
  • scoring system
  • smoking habit
  • stable angina pectoris
  • statin
  • stenosis
  • tissue
  • univariate analysis

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  • Mathiasen A.B.

  • Harutyunyan M.J.

  • Jorgensen E.

  • Helqvist S.

  • Ripa R.

  • Gotze J.P.

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