Plasticity for affective neurocircuitry: How the environment affects gene expression

  • Fox N
  • Hane A
  • Pine D
  • 128


    Mendeley users who have this article in their library.
  • 63


    Citations of this article.


We (Fox et al., 2005) recently described a gene-by- environment interaction involving child temperament and maternal social support, finding heightened behavioral inhibition in children homozygous or heterozygous for the serotonin transporter (5HTTLPR) gene short allele whose mothers reported low social support. Here, we propose a model, Plasticity for Affective Neurocircuitry, that describes the manner in which genetic disposition and environmental circumstances may interact. Children with a persistently fearful temperament (and the 5HTTLPR short allele) are more likely to experience caregiving environments in which threat is highlighted. This in turn will exacerbate an attention bias that alters critical affective neurocircuitry to threat and enhances and maintains anxious behavior in the child. (PsycINFO Database Record (c) 2010 APA )(journal abstract)

Author-supplied keywords

  • Attention bias to threat
  • Gene × environment interaction
  • Parenting
  • Temperament

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Nathan A. Fox

  • Amie A. Hane

  • Daniel S. Pine

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free