Platelet perturbations in diabetes: Implications for cardiovascular disease risk and treatment

  • Mathewkutty S
  • McGuire D
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Abstract

The prevalence of Type 2 diabetes mellitus (DM) continues to increase globally and brings with it a parallel increase in the associated cardiovascular disease complications. Despite advances in evidence-based therapies for cardiovascular disease risk modification, many of which are especially effective among patients with DM, there remains a residual degree of cardiovascular disease risk associated with DM, yielding opportunity for continued clinical advances. Given the myriad perturbations of platelet function associated with DM, improvements in antiplatelet therapies hold particular promise for this high-risk population of patients, with emerging data from ex vivo assessments and clinical outcomes trials providing a basis of support for this concept. © 2009 Expert Reviews Ltd.

Author-supplied keywords

  • abciximab
  • acetylsalicylic acid
  • anticoagulant therapy
  • antithrombocytic agent
  • cardiovascular disease
  • cardiovascular risk
  • causal attribution
  • cerebrovascular accident
  • clinical trial
  • clopidogrel
  • coronary artery disease
  • diabetes mellitus
  • diabetic patient
  • drug efficacy
  • drug megadose
  • drug treatment failure
  • eptifibatide
  • fibrinogen receptor
  • fibrinogen receptor antagonist
  • heart infarction
  • human
  • hypertension
  • in-stent restenosis
  • insulin
  • insulin resistance
  • loading drug dose
  • low drug dose
  • nitrous oxide
  • omega 3 fatty acid
  • patient compliance
  • percutaneous coronary intervention
  • placebo
  • prasugrel
  • primary prevention
  • prostacyclin
  • recommended drug dose
  • review
  • risk reduction
  • secondary prevention
  • simvastatin
  • thienopyridine derivative
  • thrombocyte disorder
  • ticlopidine
  • tirofiban

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Authors

  • S Mathewkutty

  • D K McGuire

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