Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.
CITATION STYLE
Ramazzotti, G., Faenza, I., Fiume, R., Billi, A. M., Manzoli, L., Mongiorgi, S., … Follo, M. Y. (2017, January 1). PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis. Advances in Biological Regulation. Elsevier Ltd. https://doi.org/10.1016/j.jbior.2016.10.005
Mendeley helps you to discover research relevant for your work.