Polymer attached cyclic dipeptides as catalysts for enantioselective cyanohydrin formation

  • Kim H
  • Jackson W
  • 4


    Mendeley users who have this article in their library.
  • 29


    Citations of this article.


Derivatives of cyclo-[(S)-Tyr-(S)-His], related to the 'Inoue' catalyst, cyclo-[(S)-Phe-(S)-His] have been attached to chloromethylated polystyrene and to polysiloxane polymers via spacer groups coupled to the tyrosine phenolic residue. These polymer-attached dipeptides have been shown to be efficient catalysts for the conversion of aromatic aldehydes to cyanohydrins but enantioselectivities are low. The loss of enantioselectivity relative to the Inoue catalyst has been attributed to steric effects from the substituents on the tyrosyl phenolic group. Some mechanistic comments regarding the preferred conformation of the active dipeptide are made. © 1992.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Hyun J. Kim

  • W. Roy Jackson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free