We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy. © 2009 American Chemical Society.
CITATION STYLE
Lee, S., Ryu, J. H., Park, K., Lee, A., Lee, S. Y., Youn, I. C., … Kim, K. (2009). Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo. Nano Letters, 9(12), 4412–4416. https://doi.org/10.1021/nl902709m
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