Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma

  • Skibola C
  • Lightfoot T
  • Agana L
 et al. 
  • 7


    Mendeley users who have this article in their library.
  • 13


    Citations of this article.


Broad cross-talk exists between the endocrine and immune systems. Estrogen receptor expression in lymphocytes suggests that hormonal modulation may influence lymphoma risk. Analysis of genetic polymorphisms that affect oestrogen production, such as cytochrome P450 17A1 (CYP17A1) -34T>C, may provide insight into oestrogen's role in lymphomagenesis. CYP17A1-34T>C and CYP17A1 IVS2 105A>C polymorphisms were analyzed in a non-Hodgkin lymphoma (NHL) population-based case-control study. The CYP17A1-34CC genotype was positively associated with NHL [odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis.

Author-supplied keywords

  • CYP17A1
  • Genetic associations
  • Lymphoma
  • Oestrogen
  • Single nucleotide polymorphism

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Christine F. Skibola

  • Tracy Lightfoot

  • Luz Agana

  • Alex Smith

  • Sara Rollinson

  • Andrew Kao

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free