Polymorphisms in ERCC1 and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population

  • Wang S
  • Zhao H
  • Zhou B
 et al. 
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Abstract

Excision repair cross-complementation group 1 (ERCC1) is important in repairing DNA damage and genomic instability, and polymorphisms in ERCC1 may play a role in human tumors. In this study, the relationship of two ERCC1 polymorphisms, 8092C > A and 19007G > A, with susceptibility to acute lymphoblastic leukemia (ALL) was investigated in 183 childhood patients. For the ERCC1 8092C > A polymorphism, individuals carrying the ERCC1 8092CC genotype had a significantly higher risk when compared with those carrying at least one A allele gene (AA/AC). Analysis after stratification for sex showed that the males carrying ERCC1 8092CC genotype were associated with highly significant increased risk of ALL (1.94-fold) but not females. There was no association between ERCC1 19007G > A polymorphism and ALL risk when all patients as a group were analyzed. However, the males carrying ERCC119007A allele were associated with highly significant increased risk of ALL (2.36-fold). For the ERCC1 8092C > A polymorphism, individuals under 8 years old (median age) carrying CC genotype had significantly higher risk. However, the 19007G > A polymorphism was not associated with such age-related ALL risk. These results suggest that the ERCC1 8092C > A polymorphism may be related to the occurrence of childhood ALL in a Chinese population. © 2006 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Children
  • Chinese
  • ERCC1
  • Leukemia
  • Polymorphism

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Authors

  • Si Li Wang

  • Hui Zhao

  • Bin Zhou

  • Yong Li Chen

  • Yao Zou

  • Xiao Fan Zhu

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