Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

  • Cannatelli A
  • Santos-Lopez A
  • Giani T
 et al. 
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Abstract

Inactivation of the mgrB gene, encoding a negative feed-back regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae from clinical sources. In this work we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and that mgrB inactivation is not associated with a significant biological cost.

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Authors

  • Antonio Cannatelli

  • Alfonso Santos-Lopez

  • Tommaso Giani

  • Bruno Gonzalez-Zorn

  • Gian Maria Rossolini

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