PopGen: Population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships

  • Krawczak M
  • Nikolaus S
  • Von Eberstein H
 et al. 
  • 61

    Readers

    Mendeley users who have this article in their library.
  • 218

    Citations

    Citations of this article.

Abstract

OBJECTIVE Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. DESIGN Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. RESULTS PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. CONCLUSION PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition.

Author-supplied keywords

  • Biobank
  • Complex diseases
  • Genetic epidemiology
  • Genotype-phenotype relationship
  • Population-based sampling
  • Relative risk

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Michael Krawczak

  • Susanna Nikolaus

  • Huberta Von Eberstein

  • Peter J P Croucher

  • Nour Eddine El Mokhtari

  • Stefan Schreiber

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free