Population biology of antigen presentation by MHC class I molecules

  • Parham P
  • Ohta T
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Abstract

In principle, the function of major histocompatibility complex (MHC) olecules is simple: to bind a peptide and engage a T cell. In practice, lacing this function within the context of the immune response begs uestions of population biology: How does the immune response emerge from the nteractions among populations of peptides, T cells, and MHC molecules? ithin a population of vertebrates, how does MHC polymorphism stamp ndividuality on the response? Does polymorphism confer differential dvantages in responding to parasites? How are the pressures on the MHC eflected in turnover of alleles? The role of mutation, recombination, election, and drift in the generation and maintenance of MHC class I olymorphism are considered

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Authors

  • P. Parham

  • T. Ohta

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