Porcine wound models for skin substitution and burn treatment

  • Middelkoop E
  • Van Den Bogaerdt A
  • Lamme E
 et al. 
  • 111


    Mendeley users who have this article in their library.
  • 91


    Citations of this article.


Skin regeneration is an important field of tissue engineering. Especially in larger burns and chronic wounds, present treatments are insufficient in preventing scar formation and promoting healing. Initial screening of potentially interesting products for skin substitution is usually done by in vitro tests. Before entering the clinic, however, in vivo studies in immunocompetent animals are necessary to prove efficacy and provide information on safety aspects. We have obtained extensive experience using the domestic pig as test animal for studies on skin replacement materials, including tissue engineered skin substitutes, and burn wound treatment. Two models are described: an excisional wound model for testing of dermal and epidermal substitutes and a burn wound model for contact and scald burns, which allows testing of modern wound dressings in comparison to the present gold standards in burn treatment. The results of these experiments show that in vivo testing was able to reveal (dis)advantages of the treatments which were not detected during in vitro studies. © 2003 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Animal model
  • Burn
  • Co-polymer
  • Dermis
  • Fibroblast
  • Honey
  • Scaffold

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • E. Middelkoop

  • A. J. Van Den Bogaerdt

  • E. N. Lamme

  • M. J. Hoekstra

  • K. Brandsma

  • M. M.W. Ulrich

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free