Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap

  • Griffiths E
  • Krawczyk C
  • Kong Y
 et al. 
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Abstract

The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Slap is also required in vivo for T cell-dependent immune responses. Functionally, Fyb/Slap has no apparent role in the activation of known TCR signaling pathways, F-actin polymerization, or TCR clustering. Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion.

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Authors

  • E. K. Griffiths

  • C. Krawczyk

  • Y. Y. Kong

  • M. Raab

  • S. J. Hyduk

  • D. Bouchard

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