Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared

  • Maier J
  • Walker S
  • Fantini S
 et al. 
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Abstract

Tissue glucose levels affect the refractive index of the extracellular fluid. The difference in refractive index between the extracellular fluid and the cellular components plays a role in determining the reduced scattering coefficient (micro(s)') of tissue. Hence a physical correlation may exist between the reduced scattering coefficient and glucose concentration. We have designed and constructed a frequency-domain near-infrared tissue spectrometer capable of measuring the reduced scattering coefficient of tissue with enough precision to detect changes in glucose levels in the physiological and pathological range.

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Authors

  • JS S Maier

  • SA a Walker

  • S Fantini

  • M a Franceschini

  • E Gratton

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