Posttraumatic stress disorder: Neurocircuitry and implications for potential deep brain stimulation

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  • C. O
  • J. C
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Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling psychiatric disorder that is notoriously difficult to treat. At some point in their lifetimes, 5-8% of men, 10-14% of women, and up to a quarter of combat veterans carry this diagnosis. Despite pharmacological and behavioral therapies, up to 30% of patients are still symptomatic 10 years after initial diagnosis. Recent advances in imaging have implicated changes in the limbic and autonomic corticostriatopallidothalamocortical (CSPTC) circuitry in the pathogenesis of this disease. Deep brain stimulation modulates CSPTC circuits in movement and other neuropsychiatric disorders. In this review, we discuss the salient clinical features and neurocircuitry of PTSD and propose a neuromodulation strategy for the disorder. Copyright (copyright) 2013 S. Karger AG, Basel.

Author-supplied keywords

  • Parkinson disease
  • amygdaloid nucleus
  • anticonvulsant therapy
  • anticonvulsive agent
  • behavior therapy
  • benzodiazepine derivative
  • brain depth stimulation
  • brofaromine
  • carbamazepine
  • cingulate gyrus
  • cognitive therapy
  • comorbidity
  • corticotropin releasing factor
  • cycloserine
  • drug efficacy
  • functional magnetic resonance imaging
  • human
  • hypothalamus hypophysis adrenal system
  • inositol
  • monoamine oxidase inhibitor
  • naltrexone
  • neuroimaging
  • neuromodulation
  • neuropathology
  • neurotoxicity
  • nonhuman
  • olanzapine
  • pathogenesis
  • phenelzine
  • posttraumatic stress disorder
  • prazosin
  • psychosurgery
  • psychotherapy
  • randomized controlled trial (topic)
  • review
  • reward
  • risperidone
  • serotonin uptake inhibitor
  • single photon emission computer tomography
  • substance abuse
  • trauma focused cognitive behavioral therapy
  • treatment response
  • tricyclic antidepressant agent
  • ventromedial prefrontal cortex

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  • Taghva A.

  • Oluigbo C.

  • Corrigan J.

  • Rezai A.R.

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