Posttraumatic Stress Disorder: Neurocircuitry and Implications for Potential Deep Brain Stimulation

  • Taghva A
  • Oluigbo C
  • Corrigan J
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling psychiatric disorder that is notoriously difficult to treat. At some point in their lifetimes, 5-8% of men, 10-14% of women, and up to a quarter of combat veterans carry this diagnosis. Despite pharmacological and behavioral therapies, up to 30% of patients are still symptomatic 10 years after initial diagnosis. Recent advances in imaging have implicated changes in the limbic and autonomic corticostriatopallidothalamocortical (CSPTC) circuitry in the pathogenesis of this disease. Deep brain stimulation modulates CSPTC circuits in movement and other neuropsychiatric disorders. In this review, we discuss the salient clinical features and neurocircuitry of PTSD and propose a neuromodulation strategy for the disorder

Author-supplied keywords

  • Brain
  • Circuits
  • Deep Brain Stimulation
  • Disease
  • Movement
  • Neuromodulation
  • Neurosurgery
  • Patients
  • Pt
  • Review
  • Stimulation
  • Stress
  • USA
  • Veterans
  • brain stimulation
  • diagnosis
  • imaging
  • potential
  • psychiatric disorder
  • therapy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 23548850


  • A Taghva

  • C Oluigbo

  • J Corrigan

  • A R Rezai

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free