Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: Experience from a multicentre study

  • Giamarellou H
  • Giamarellos-Bourboulis E
  • Repoussis P
 et al. 
  • 37

    Readers

    Mendeley users who have this article in their library.
  • 70

    Citations

    Citations of this article.

Abstract

In order to assess the diagnostic value of procalcitonin, 158 patients with febrile neutropenia from centres across Europe were studied. Patients with fever were diagnosed on the basis of either: (1) clinical, radiological and microbiological criteria; or (2) the procalcitonin value. In the latter case, concentrations of 0.5-1.0 ng/mL were considered diagnostic of localised infection, concentrations of 1.0-5.0 ng/mL of bacteraemia, and concentrations of > 5.0 ng/mL of severe sepsis. Procalcitonin and C-reactive protein were estimated daily in serum by immunochemiluminescence and nephelometry, respectively. Overall, the sensitivity (specificity) of procalcitonin for bacteraemia was 44.2% (64.3%) at concentrations of 1.0-5.0 ng/mL, and 83.3% (100%) for severe sepsis at concentrations of > 5.0 ng/mL. It was concluded that procalcitonin is a marker strongly suggestive of severe sepsis at concentrations of > 5.0 ng/mL. Estimated concentrations of < 0.5 ng/mL indicate that infection is unlikely, but it was observed that bacteraemia associated with coagulase-negative staphylococci may fail to elevate serum procalcitonin levels.

Author-supplied keywords

  • Bacteramia
  • C-reactive protein
  • Diagnosis
  • Fever
  • Procalcitonin

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • H. Giamarellou

  • E. J. Giamarellos-Bourboulis

  • P. Repoussis

  • L. Galani

  • N. Anagnostopoulos

  • P. Grecka

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free