The potential therapeutic targets to bone pain induced by cancer metastasis

  • J. W
  • Y. W
  • J. S
 et al. 
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About 75-90% of patients with advanced metastatic cancer experience significant cancer pain. Bone cancer pain is one of the most common pains experienced by patients with advanced breast, prostate, or lung cancer. It is characterized by significant skeletal remodeling, fractures, pain, and anemia, all of which reduce the functional status, quality of life, and survival of the patient. Recent years have seen great progress toward alleviating bone pain with the identification of a range of chemicals as well as receptors modulating cancer pain progression. However, the complicated interactions among these factors and, sometimes, the contradicting effects of the same factor in different pathways make it difficult to spot individual effective targets. The sheer quantity of the chemicals involved and the limited understanding from animal models are the constraints in the development of effective therapies for cancer bone pain. In this review, key targets will be discussed along the pain transduction pathway, including peripheral pain sensation, spinal cord transduction pathway, and the central nervous system, to offer a logical and systematic study for the development of combined anti-bone pain treatments.

Author-supplied keywords

  • *bone metastasis
  • *bone pain
  • *cancer pain
  • *metastasis
  • *nervous system
  • *pain
  • 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13
  • T lymphocyte
  • activating transcription factor 3
  • allodynia
  • anemia
  • animal model
  • astrocyte
  • bone cancer
  • bone mass
  • bone metastasis
  • breast
  • cancer cell
  • cancer pain
  • central nervous system
  • cyclic AMP dependent protein kinase
  • cyclic AMP responsive element binding protein
  • denosumab
  • down regulation
  • endothelium cell
  • enzyme activation
  • ephrin
  • ephrin b
  • ephrin receptor B1
  • exoenzyme C3
  • forskolin
  • fracture
  • functional status
  • gene overexpression
  • gene silencing
  • glia cell
  • human
  • interleukin 33
  • interleukin 6
  • lung cancer
  • macrophage
  • male
  • mast cell
  • n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesu
  • n methyl dextro aspartic acid receptor
  • neoplasm
  • nephroblastoma overexpressed protein
  • nerve cell excitability
  • nerve growth factor
  • neutralizing antibody
  • nociception
  • nonhuman
  • osteoclast differentiation factor
  • osteoclastogenesis
  • osteolysis
  • pain receptor
  • patient
  • peripheral nerve
  • prostaglandin E2
  • prostate
  • prostate cancer
  • protein phosphorylation
  • proteinase activated receptor 2
  • purinergic P2X3 receptor
  • quality of life
  • receptor
  • receptor activator of nuclear factor kappa B
  • review
  • signal transduction
  • sodium channel Nav1.8
  • spinal cord
  • spinal ganglion
  • stroma cell
  • survival
  • therapy
  • toll like receptor 4
  • tumor necrosis factor
  • unclassified drug
  • unindexed drug
  • upregulation
  • vanilloid receptor 1
  • vanilloid receptor 4
  • visinin
  • visinin like protein 1

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  • Wu J.

  • Wei Y.

  • Shi J.

  • Chen F.

  • Huang G.

  • Chen J.

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