The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease. © 2011 Macmillan Publishers Limited. All rights reserved.
CITATION STYLE
Nagahara, A. H., & Tuszynski, M. H. (2011, March). Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nature Reviews Drug Discovery. https://doi.org/10.1038/nrd3366
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