Potential therapeutic uses of {BDNF} in neurological and psychiatric disorders

  • Nagahara A
  • Tuszynski M
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Abstract

The growth factor brain-derived neurotrophic factor {(BDNF)} and its receptor tropomyosin-related kinase receptor type B {(TRKB)} are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of {BDNF} suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in {BDNF-related} research in the central nervous system, with an emphasis on the possible therapeutic application of {BDNF} in modifying fundamental processes underlying neural disease.

Author-supplied keywords

  • Adult Alzheimer Disease Amyotrophic Lateral Sclero

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Authors

  • Alan Nagahara

  • Mark Tuszynski

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