PPAR gamma and the treatment of insulin resistance

  • Olefsky J
  • Saltiel A
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Numerous studies across several population groups have indicated that insulin resistance plays a central role in the development of type 2 diabetes mellitus (T2DM). Moreover, this disorder is also strongly associated with other metabolic syndromes, including hypertension, dyslipidemias and polycystic ovarian syndrome (PCOS). Recent advances have demonstrated that pharmacological agents of the thiazolidinedione class can reverse insulin resistance and profoundly improve many of these associated symptoms. These effects have been documented in a variety of genetic and acquired animal models of insulin resistance, as well as in numerous clinical trials in patients with insulin resistance. These compounds appear to enhance insulin action by modulating the activity of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma. This activation results in changes in the expression of a number of genes that are critically involved in glucose and lipid metabolism, as well as in insulin signal transduction. While precise events that occur downstream from PPAR gamma modulation remain uncertain, new insights are emerging from knockout studies in mice and the identification of genetic variants in humans. These findings indicate that there is still much to learn about the molecular biology and physiology of these interesting receptors, and that research in this area can lead to more effective and safer drugs to treat insulin resistance and associated syndromes. [References: 50]

Author-supplied keywords

  • AET-6
  • Activation
  • Animal
  • Clinical
  • Clinical trial
  • Development
  • Diabetes
  • Diabetes mellitus
  • Disorder
  • Drug
  • Dyslipidemia
  • Dyslipidemias
  • Expression
  • Gene
  • Genetic
  • Glucose
  • Human
  • Humans
  • Hypertension
  • Identification
  • Insulin
  • Insulin resistance
  • Knockout
  • Lipid
  • Metabolic
  • Metabolic syndrome
  • Metabolism
  • Mice
  • Model
  • Molecular
  • Molecular biology
  • Nuclear
  • Nuclear receptor
  • PPAR
  • PPAR gamma
  • PPAR-gamma
  • Peroxisome
  • Peroxisome proliferator activated receptor
  • Receptor
  • Research
  • Resistance
  • SERM
  • Signal
  • Signal transduction
  • Syndrome
  • Thiazolidinedione
  • Treat
  • Type 2
  • Type 2 diabetes
  • [Review]
  • effect
  • gamma
  • lipid metabolism
  • physiology
  • treatment

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links


  • J M Olefsky

  • A R Saltiel

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free