A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms

  • Little J
  • Safdar A
  • Wilkin G
 et al. 
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High-intensity interval training (HIT) induces skeletal muscle metabolic and performance adaptations that resemble traditional endurance training despite a low total exercise volume. Most HIT studies have employed "all out", variable-load exercise interventions (e.g., repeated Wingate Tests) that may not be safe, practical and/or well tolerated by certain individuals. Our purpose was to determine the performance, metabolic and molecular adaptations to a more practical model of low-volume HIT. Seven men (21+/-0.4 yr, VO2peak = 46+/-2 ml.kg-1[middot]min-1) performed 6 training sessions over 2 wk. Each session consisted of 8-12 x 60 s intervals at approximately 100% of peak power output elicited during a ramp VO2 peak test (355+/-10 W) separated by 75 s of rest. Training increased exercise capacity, as assessed by significant improvements on both 50 kJ and 750 kJ cycling time trials (p

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  • J P Little

  • A S Safdar

  • G P Wilkin

  • M A Tarnopolsky

  • M J Gibala

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