Preclinical mouse models of osteosarcoma

  • Uluçkan Ö
  • Segaliny A
  • Botter S
 et al. 
  • 45


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Osteosarcoma is the most common form of primary bone tumors with high prevalence in children. Survival rates of osteosarcoma are low, especially in the case of metastases. Mouse models of this disease have been very valuable in investigation of mechanisms of tumorigenesis, metastasis, as well as testing possible therapeutic options. In this chapter, we summarize currently available mouse models for osteosarcoma and provide detailed methodology for the isolation of cell lines from genetically engineered mouse models (GEMMs), gene modification and tumor cell injection methods, as well as imaging techniques.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Özge Uluçkan

  • Aude Segaliny

  • Sander Botter

  • Janice M Santiago

  • Anthony J Mutsaers

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free