Predicting the histopathological grade of cerebral gliomas using high b value MR DW imaging at 3-tesla

  • Alvarez-Linera J
  • Benito-León J
  • Escribano J
 et al. 
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Abstract

BACKGROUND: Our aim was to prospectively assess whether magnetic resonance (MR) diffusion-weighted (DW) imaging using high b values can predict better than b value of 1,000 s/mm(2) the histopathological grade of cerebral gliomas.

METHODS: Fifty-four patients with histologically verified brain gliomas (35 high-grade and 19 low-grade gliomas) underwent MR DW imaging. Isotropic DW images and apparent diffusion coefficient (ADC) were obtained with b values of 1,000 and 3,000 s/mm(2). Each tumor was evaluated as being hyperintense, iso-intense or hypointense to normal, contralateral-hemisphere white matter.

RESULTS: Most of the patients with high- and low-grade gliomas showed areas of increased signal intensity on their isotropic images, obtained with a b value of 1,000 s/mm(2). However, with a b value of 3,000 s/mm(2) the areas of increased signal intensity were seen in 97.1% of the high-grade gliomas, while 94.7% of the low-grade gliomas showed no area of increased signal intensity. The mean area under the ROC curve for ADC ratio, obtained with a b value of 3,000 s/mm(2), was significantly higher than that obtained with 1,000 s/mm(2) (.932 vs. .856, P= .04).

CONCLUSION: High b value DW MR might be useful as a complementary tool in preoperative assessment of the histopathological grading of cerebral gliomas.

Author-supplied keywords

  • ADC
  • Brain tumor
  • Central nervous system
  • Diffusion-weighted MR
  • b value

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Authors

  • Juan Alvarez-Linera

  • Julián Benito-León

  • Jose Escribano

  • G. Rey

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