Predictive factors for QTc prolongation in schizophrenic patients taking antipsychotics

  • Lin C
  • Chen M
  • Wang S
 et al. 
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Abstract

Background and Purpose: The rate-corrected electrocardiographic QT (QTc) interval may significantly increase in schizophrenic patients taking antipsychotics. QTc prolongation is a risk factor for development of arrhythmia. The objective of this study was to assess the predictors of QTc prolongation in schizophrenic patients taking antipsychotic medication. Methods: Electrocardiograms were obtained from 138 controls and 412 schizophrenic inpatients taking antipsychotics. QTc prolongation was defined as a mean value of 2 standard deviations above the controls. Predictors were analyzed with a logistic regression model. Results: Based on data obtained from controls, QTc prolongation was defined as a QTc greater than 421 ms. Logistic regression analysis showed that significant predictors for QTc prolongation were: female gender (odds ratio, 3.355 [95% CI, 1.767-6.371]); increased age (1.040 [1.011-1.069] ); and increased doses of some antipsychotics, including clozapine (1.006 [1.003-1.008]), chlorpromazine (1.003 [1.002-1.005] ), thioridazine (1.007 [1.003-1.011]), and sulpiride (1.001 [1.001-1.002] ). Conclusions: Predictors of the QTc prolongation in schizophrenic patients taking antipsychotic medications were female gender, old age, and treatment with clozapine, chlorpromazine, thiroridazine, or sulpiride.

Author-supplied keywords

  • Antipsychotic agents
  • Long QT syndrome
  • Risk factors
  • Torsade de pointes

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Authors

  • C.-H. Lin

  • M.-C. Chen

  • S.-Y. Wang

  • C.-Y. Lin

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