Predisposition to atopic symptoms to inhaled antigens may protect from childhood type 1 diabetes

  • Mattila P
  • Tarkkanen J
  • Saxen H
 et al. 
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Abstract

To assess the inverse association between type 1 diabetes and asthma to establish whether environmental and/or genetic factors predisposing to asthma or to atopic symptoms to inhaled antigens protect from diabetes. RESEACH DESIGN AND METHODS: Questionnaires were returned by 306 probands with childhood type 1 diabetes, their 506 nonaffected siblings, and 406 age- and sex-matched unaffected population control subjects. The main outcome measures were self-reported physician-diagnosed asthma and atopic symptoms to animal dust and pollen.

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Authors

  • Petri S. Mattila

  • Jussi Tarkkanen

  • Harri Saxen

  • Janne Pitkäniemi

  • Marjatta Karvonen

  • Jaakko Tuomilehto

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