Journal article

Prefrontal cortex fMRI signal changes are correlated with working memory load.

Manoach D, Schlaug G, Siewert B, Darby D, Bly B, Benfield A, Edelman R, Warach S ...see all

Neuroreport: An International Journal for the Rapid Communication of Research in Neuroscience, vol. 8, issue 2 (1997) pp. 545-549 Published by Lippincott Williams & Wilkins

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Investigates whether a nonspatial working memory (WM) task would activate the dorsolateral prefrontal cortex (DLPFC) and whether activation would be correlated with WM load. Using functional magnetic resonance imaging (MRI), the authors measured regional brain signal changes in 12 normal Ss aged 25-43 yrs during a continuous performance, choice reaction time task that requires WM. A high WM load condition was compared with a non-WM choice reaction time control condition (WM effect) and a low WM load condition (load effect). Significant changes in signal intensity occurred in the DLPFC, frontal motor regions and the intraparietal sulcus (IPS) in both comparisons. These findings support the role of DLPFC and IPS in WM and suggest that signal changes in DLPFC correlate with WM load. (PsycINFO Database Record (c) 2005 APA, all rights reserved)

Author-supplied keywords

  • Human Channel Capacity
  • Prefrontal Cortex
  • Short Term Memory
  • high vs low working memory demand, activation of d

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  • Dara S Manoach

  • Gottfried Schlaug

  • Bettina Siewert

  • David G Darby

  • Benjamin Martin Bly

  • Andrew Benfield

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