Prefrontal cortex transcranial direct current stimulation associated with aerobic exercise change aspects of appetite sensation in overweight adults

  • Montenegro R
  • Okano A
  • Cunha F
 et al. 
  • 134


    Mendeley users who have this article in their library.
  • 40


    Citations of this article.


This study investigated whether transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex (DLPFC) isolated or combined with aerobic exercise influenced the desire to eat, hunger, and satiety in overweight subjects. Nine volunteers underwent anodal or sham tDCS (2mA; 20min) over DLPFC and isocaloric exercise bouts (70%VO2R; ~200kcal). The appetite sensations were evaluated by visual analogue scales at four moments: I - Baseline; II - After tDCS; III - Post-Exercise and IV - 30-min Post-Exercise. The tDCS on left DLPFC decreased the desire to eat at baseline (tDCS -26% vs. -14% Sham). The tDCS associated with exercise had greater suppressing effect in desire to eat compared to either tDCS or exercise alone (tDCS -39% vs. -27% Sham). Moreover, the tDCS associated with exercise decreased hunger (tDCS -48% vs. 36% Sham) and increased satiety (tDCS 28% vs. 7% Sham) immediately after exercise. The post-exercise 30-min recovery elicited an overall increase in appetite. However the increase in desire to eat and hunger after recovery was lower after tDCS (29% and 13%, respectively) compared to sham stimulation (77% and 113%, respectively). These findings in overweight subjects indicate that the combination of tDCS over DLPFC and aerobic exercise induced greater decrease in appetite sensations compared to anodal tDCS or exercise alone. © 2011 Elsevier Ltd.

Author-supplied keywords

  • Brain polarization
  • Brain stimulation
  • Central regulation of appetite
  • Food cravings
  • Obesity
  • TDCS

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Rafael A. Montenegro

  • Alexandre H. Okano

  • Felipe A. Cunha

  • Jonas L. Gurgel

  • Eduardo B. Fontes

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free