Preirradiation sinus mucosal disease in patients with nasopharyngeal carcinoma.

  • Huang C
  • Chang P
  • Lee T
 et al. 
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PURPOSE: The objective of this study was to evaluate the incidence
and the possible risk factors for preirradiation abnormalities of
the sinus mucosa in patients with nasopharyngeal carcinoma (NPC)
by magnetic resonance imaging. MATERIALS AND METHODS: Medical records
and magnetic resonance imaging results were reviewed and compared
between a group of patients with NPC and a control group. The Lund-Mackay
system for staging of rhinosinusitis (Lund score) was used as a tool
for the investigation. RESULTS: The incidence of sinus mucosal abnormalities
was 32.1% in the NPC group and 20.7% in the control group (P =
.041). The patients with NPC demonstrated a higher incidence of sinus
abnormalities in nearly all sinuses. However, only the incidence
of disease in the posterior ethmoid (P = .002) and sphenoid sinus
(P = .006) was significantly increased in patients with NPC. The
incidence and the severity of sinus abnormalities in male patients
with NPC were significantly higher than that in female patients.
Patients with advanced T stage showed significantly higher Lund scores
(P = .015) than patients with early T stage. CONCLUSION: The results
supported the hypothesis that patients with NPC might be prone to
have chronic infection and might be partially immunocompromised by
Epstein-Barr virus. Female patients may have an inherited genetic
advantage that protects against Epstein-Barr virus infection or lessens
its devastating effects.

Author-supplied keywords

  • 80 and over; Carcinoma
  • Adolescent; Adult; Aged; Aged
  • Squamous Cell
  • epidemiology/pathology; Case-Control Studies; Fem
  • epidemiology/pathology; Neoplasm Staging
  • epidemiology/radiography; Retrospective Studies;
  • epidemiology; Young Adult
  • methods; Paranasal Sinus Diseases
  • pathology; Nasopharyngeal Neoplasms

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  • Chi-Che Huang

  • Po-Hung Chang

  • Ta-Jen Lee

  • Chi-Cheng Chuang

  • Joseph Tung-Chieh Chang

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