Preliminary evidence for reduced frontal white matter integrity in subjects at ultra-high-risk for psychosis

  • Peters B
  • Schmitz N
  • Dingemans P
 et al. 
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This study examines white matter integrity in subjects at ultra-high risk (UHR) for psychosis with diffusion tensor imaging (DTI), in comparison with recent onset schizophrenia patients. Ten male subjects at UHR for psychosis (mean age 21.6 years, standard deviation (SD)=2.8) were included after assessment with the Structured Interview for Prodromal Syndromes. Eight male patients with a recent onset of schizophrenia and two male patients with schizoaffective disorder (21.2 years, SD=3.0) were recruited from the Adolescent Clinic, Amsterdam. All recent-onset patients used antipsychotic medication. Ten male healthy controls (21.1 years, SD=2.8) were included. All participants were matched for handedness and level of education. We identified reduced FA values in the recent-onset schizophrenia patients compared to controls in WM of the parietal lobe bilaterally (24, −66, 51; Z=6.71; Pcb0.001; 22, −65, 35; Z=5.6; Pc=0.050), left superior temporal lobe (−22, 0, 55; Z=5.89; Pc=0.048), right temporal lobe, insula region (26, −26, 14; Z=4.20; pb0.001) and left frontal lobe (−32, 44, 01; Z=6.70; pb0.001). This discrepancy of possible lack of frontal WM abnormalities in our schizophrenia patients and presence of significant frontal WM clusters in the UHR subjects could be related to the clinical heterogeneity of schizophrenia. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

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  • B. D. Peters

  • N. Schmitz

  • P. M. Dingemans

  • T. A. van Amelsvoort

  • D. H. Linszen

  • L. de Haan

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