Preliminary studies on two vegetable oil based self emulsifying drug delivery system (SEDDS) for the delivery of metronidazole, a poorly water soluble drug

  • Obitte N
  • Ezeiruaku H
  • Onyishi V
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Abstract

A preliminary evaluation was carried out on metronidazole-loaded Self Emulsifying Drug Delivery System (SEDDS) using two vegetable oils-Palm Kernel Oil (PKO) and Palm Oil (PO). Purifn. of oils, drug soly. in the oils, pre/post formulation isotropicity tests, emulsification times and release studies of metronidazole from the SEDDS were carried out. Results indicated soly. values of 4.441 and 4.654%wt./wt., resp. for metronidazole in PKO and PO. Preformulation isotropicity test revealed that out of the 24 batches evaluated 10 of the SEDDS formulations contg. different oil: surfactant ratios and PKO:PO admixts. were found to be isotropic after 5 h. However when the SEDDS were loaded with metronidazole there was a redn. in the no. (to 7) of formulations that maintained isotropicity and stability after 72 h. All the batches had emulsification times of less than two minutes except batch 4D with oil:surfactant concn. of 50:50. The release profile showed that most of the formulations released 50% of drug in less than 8 min and 85% of drug in less than 30 min. We therefore conclude that SEDDS contg. the two vegetable oils are potential alternatives when immediate release and delivery of metronidazole is the primary motivation. [on SciFinder(R)]

Author-supplied keywords

  • Emulsification time
  • Isotropic
  • Metronidazole
  • Self-emulsifying drug delivery system
  • Vegetable oil

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Authors

  • N. C. Obitte

  • H. Ezeiruaku

  • V. I. Onyishi

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