Prenatal drug exposure effects on subsequent vulnerability to drug abuse

  • Glantz M
  • Chambers J
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Research has shown that both prenatal alcohol and tobacco exposure are associated with increased risk of significant adverse medical, developmental, and behavioral outcomes including substance abuse. Research on the outcomes of prenatal exposure to illicit drugs (PNDE) has also found increased physical and behavioral problems for gestationally drug-exposed children. However, a clear picture has not emerged on whether the consequences of PNDE are independent from those associated with having a substance abusing parent and whether PNDE increases vulnerability to drug abuse. Because of its typical co-occurrence with factors inherent in having a drug-abusing parent, PNDE is at least a marker of significant increased risk for a range of negative outcomes including greater vulnerability to substance abuse. Although a review of the relevant research literatures indicates that the direct consequences of PNDE appear to be generally both subtle and nonglobal, PNDE does appear to have negative developmental and behavioral outcomes, and there is evidence that it is a modest direct contributor to increased substance abuse vulnerability. © 2006 Cambridge University Press.

Author-supplied keywords

  • Attitude
  • Child
  • Child of Impaired Parents
  • Female
  • Humans
  • Life Style
  • Parent-Child Relations
  • Parenting
  • Prefrontal Cortex
  • Prenatal Exposure Delayed Effects
  • Social Behavior Disorders
  • Social Environment
  • Street Drugs
  • Substance-Related Disorders
  • alcoholism
  • behavior disorder
  • brain disease
  • cannabis
  • child abuse
  • child parent relation
  • cigarette smoking
  • cocaine
  • comorbidity
  • conduct disorder
  • developmental disorder
  • drug abuse
  • environmental factor
  • human
  • illicit drug
  • lifestyle
  • medical research
  • mental disease
  • nonhuman
  • opiate
  • parental behavior
  • physical disease
  • pregnancy
  • prenatal drug exposure
  • priority journal
  • review
  • risk assessment
  • substance abuse
  • temperament
  • tobacco dependence

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  • M D Glantz

  • J C Chambers

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