Preparation and characterization of a pseudo-template imprinted polymer with a chirality-matching monomer for the separation of cinchona alkaloids by high-performance liquid chromatography

  • Jiang J
  • Zhou Q
  • Kang C
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 1


    Citations of this article.


A hydroquinidine-imprinted stationary selector with chiral recognition for cinchona alkaloids was prepared by bulk polymerization with (+)-(2R,3R)-N, N′-diallyl-L-tartardiamide as a functional monomer, and the recognition properties of the polymers for quinidine (QD) were analyzed with high-performance liquid chromatography. By optimizing the preparation conditions and chromatographic conditions, such as the ratio of the mobile phase and flow rate, QD and quinine could be completely separated to the best resolution of 2.25. The chiral molecularly imprinted polymers (CMIPs) combined the virtues of traditional brush-type chiral selectors with existing CMIPs. The results show a substantial synergistic effect between the chiral monomer and the chiral cavity of the resulting CMIPs in chiral recognition. Copyright © 2013 Wiley Periodicals, Inc.

Author-supplied keywords

  • bulk polymerization
  • chiral separation
  • cinchona alkaloids
  • high performance liquid chromatography
  • synergistic effect

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free