A propranolol molecule-imprinted monolithic stationary phase (MIMSP) was synthesized by in situ technique. The recognition mechanism of the polymers and the influences of some chromatographic conditions were examined by high-performance liquid chromatography (HPLC). The imprinted polymers showed much higher selectivity for β-blockers than the nonimprinted polymers (NIPs) did, which proves the successful preparation of propranolol-imprinted polymers by using an in situ technique. Then, this technique was used to prepare a molecularly imprinted polymer solid-phase extraction column to concentrate propranolol from biological samples. The results showed that the imprinted solid-phase extraction column could selectively enrich and purify propranolol from biological samples, such as plasma. Copyright © Taylor & Francis Group, LLC.
CITATION STYLE
Zhang, Q., Fu, Q., Amut, E., Fang, Q., Zeng, A., & Chang, C. (2009). Preparation and evaluation of propranolol-imprinted monolithic stationary phase by in situ technique and application in analysis of propranolol in biological samples. Analytical Letters, 42(3), 536–554. https://doi.org/10.1080/00032710802677084
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