Preparation and evaluation of propranolol-imprinted monolithic stationary phase by in situ technique and application in analysis of propranolol in biological samples

  • Zhang Q
  • Fu Q
  • Amut E
 et al. 
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Abstract

A propranolol molecule-imprinted monolithic stationary phase (MIMSP) was synthesized by in situ technique. The recognition mechanism of the polymers and the influences of some chromatographic conditions were examined by high-performance liquid chromatography (HPLC). The imprinted polymers showed much higher selectivity for -blockers than the nonimprinted polymers (NIPs) did, which proves the successful preparation of propranolol-imprinted polymers by using an in situ technique. Then, this technique was used to prepare a molecularly imprinted polymer solid-phase extraction column to concentrate propranolol from biological samples. The results showed that the imprinted solid-phase extraction column could selectively enrich and purify propranolol from biological samples, such as plasma.

Author-supplied keywords

  • Biological samples
  • Molecularly imprinted polymer
  • Monolithic stationary phase
  • Propranolol

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Authors

  • Qianqian Zhang

  • Qiang Fu

  • Elijan Amut

  • Qi Fang

  • Aiguo Zeng

  • Chun Chang

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