Preparation, purification and morphology of polymeric nanoparticles as drug carriers.

  • Venier-Julienne M
  • Benoit J
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Abstract

The aim of this work was to prepare biodegradable poly(D,L-lactic acid-co-glycolic acid) copolymer (PLAGA) nanoparticles by the solvent evaporation process and to incorporate an antifungal antibiotic, amphotericin B. Blank nanoparticles obtained were 130 +/- 27 nm in diameter. When amphotericin B was added in the organic phase, the final suspension showed two populations due to unbound drug. Free amphotericin B was removed by contacting the nanoparticle suspension with an adsorbent polymer. Amberlite XAD16, and subsequently ultrafiltering the medium. The drug payload was between 0.7 and 1.3%. To gain more insight in the cause of this low loading, we studied progesterone-loaded nanoparticles using PLAGA and polystyrene as models because progesterone and these polymers exhibit a degree of miscibility. In the case of polystyrene, nanoparticle drug content reached 8%.

Author-supplied keywords

  • Amphotericin B
  • Amphotericin B: administration & dosage
  • Drug Carriers
  • Lactic Acid
  • Polyglycolic Acid
  • Polymers
  • Polymers: administration & dosage
  • Progesterone
  • Progesterone: administration & dosage

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Authors

  • M C Venier-Julienne

  • J-P Benoit

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