Pre-surgical cortical activation to food pictures is associated with weight loss following bariatric surgery

  • Ness A
  • Bruce J
  • Bruce A
 et al. 
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Abstract

BACKGROUND: Recent research suggests that preintervention functional magnetic resonance imaging (fMRI) data may predict weight loss outcomes among patients who participate in a behavioral weight loss plan. No study has examined whether presurgical brain activation can predict outcomes following bariatric surgery. METHOD: The aim of the present study was to determine if brain activations during a presurgical fMRI food-motivation paradigm are associated with weight loss 3 and 6 months following laparoscopic adjustable gastric banding (LAGB). Nineteen participants viewed food and nonfood pictures from a well-established food motivation paradigm during an fMRI scanning session before LAGB surgery. Weight was assessed presurgery and 3 and 6 months postsurgery; data for all participants was available at each time point. fMRI data were analyzed using the BrainVoyager QX statistical package. Whole brain voxelwise correlations of presurgery (food-nonfood) brain activation and weight, corrected for multiple comparisons, were performed to analyze the relationship between presurgical brain activation and subsequent weight loss. The settings were a medical university brain imaging center and 2 surgical weight loss centers in a major metropolitan area. RESULTS: Increased activity in frontal regions associated with cognitive control (medial, middle, superior frontal gyrus) and posterior cingulate cortex was associated with weight loss following LAGB. CONCLUSION: We found that neural activity in previously established regions associated with cognitive and behavioral self-regulation predicts weight loss following bariatric surgery. These preliminary findings highlight the role of neural circuitry in the success and maintenance of weight loss and suggest a possible future use of fMRI in screening LAGB surgery candidates.

Author-supplied keywords

  • *Weight Loss
  • Adult
  • Age Factors
  • Body Mass Index
  • Cerebral Cortex/physiology
  • Feeding Behavior/*psychology
  • Female
  • Follow-Up Studies
  • Food
  • Gastric Bypass/methods/*psychology
  • Humans
  • Laparoscopy/methods
  • Magnetic Resonance Imaging/methods
  • Male
  • Middle Aged
  • Monte Carlo Method
  • Obesity, Morbid/diagnosis/*psychology/*surgery
  • Photic Stimulation/*methods
  • Photography
  • Postoperative Care/methods
  • Preoperative Care/methods
  • Risk Assessment
  • Sex Factors
  • Treatment Outcome

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Authors

  • A Ness

  • J Bruce

  • A Bruce

  • R Aupperle

  • R Lepping

  • L Martin

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