Prevalence and behavioural risk factors of Staphylococcus aureus nasal colonization in community-based injection drug users

  • Leung N
  • Padgett P
  • Robinson D
 et al. 
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Abstract

SUMMARY The aims of this study were to identify Staphylococcus aureus nasal colonization prevalence, behavioural risk factors, and to determine staphylococcal protein A (spa) types in community-based injection drug users (IDUs). Nasal swabs were collected and methicillin susceptibility testing and spa/SCCmec typing were performed on S. aureus isolates. Generalized estimating equations were used to report adjusted odds ratios and 95% confidence intervals. Of the 440 participants, 24·1% were colonized and 5·7% had methicillin-resistant S. aureus (MRSA). Colonization was associated with age, employment/marital status, and the presence of scabs but not with sexually transmitted disease co-infection, HIV status, antibiotic use, hospitalization, or drug treatment programme participation. The USA300 MRSA clone spa types were most common, but 15/49 spa types were new to one of the international databases. Community-based IDUs appear to have different risk factors compared to IDUs from clinical studies. In addition, the number of newly identified spa types indicates a diverse, understudied population.

Author-supplied keywords

  • Drug users
  • methicillin-resistant
  • prevalence
  • staphylococcal epidemiology

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Authors

  • N. S. Leung

  • P. Padgett

  • D Ashley Robinson

  • Eric Luis Brown

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