Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescents

  • Smith E
  • Swarnavel S
  • Ritchie J
 et al. 
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Abstract

OBJECTIVE: Human papillomavirus (HPV) in the oral cavity or oropharynx is associated with an increased risk of laryngeal papillomatosis, head and neck cancer, and cervical and other genital cancers. We evaluated the prevalence of HPV DNA in the oral cavity/oropharynx in a cross section of children aged 2 weeks to 20 years. METHODS: A risk factor questionnaire and oral exfoliated cells were collected from children (N = 1235). HPV DNA was detected using PCR, dot blot hybridization, and DNA sequencing. RESULTS: The HPV prevalence was 1.9% in the oral cavity/oropharynx of children. A bimodal age distribution was observed with the highest HPV prevalence in the youngest and oldest groups: 2.5% aged

Author-supplied keywords

  • 20
  • ADOLESCENTS
  • AGE DISTRIBUTION
  • Adolescent
  • Alphapapillomavirus
  • Article
  • BLOT HYBRIDIZATION
  • CANCERS
  • CAVITY
  • CLASSIFICATION
  • Child,Preschool
  • DNA
  • DNA sequencing
  • DOT
  • GENITAL CANCER
  • GENITAL WARTS
  • HEAD
  • HEALTH
  • HPV
  • HPV DNA
  • HPV infection
  • HPV prevalence
  • HPV vaccination
  • HPV-6
  • HPV-DNA
  • HPV-INFECTION
  • HPV6
  • HUMAN-PAPILLOMAVIRUS
  • HUMANS
  • Hospitals,University
  • INCREASED RISK
  • INFANTS
  • Infant,Newborn
  • Iowa
  • Isolation & Purification
  • LARYNGEAL PAPILLOMATOSIS
  • N
  • NECK
  • NECK-CANCER
  • NO
  • ORAL CAVITY
  • PAPILLOMATOSIS
  • PAPILLOMAVIRUS INFECTIONS
  • PCR
  • PHARYNX
  • PUBLIC-HEALTH
  • Population
  • RATES
  • RISK FACTOR
  • RISK-FACTORS
  • SECTION
  • Sequence Analysis,DNA
  • Sex Distribution
  • Transmission
  • USA
  • adult
  • age
  • aged
  • cancer
  • cell
  • cells
  • cervical
  • child
  • children
  • conclusion
  • disease
  • diseases
  • dot blot
  • dot blot hybridization
  • epidemiology
  • factor
  • factors
  • female
  • genital
  • genital wart
  • head and neck
  • head and neck cancer
  • human
  • human papillomavirus
  • hybridization
  • infant
  • infection
  • male
  • method
  • methods
  • mouth
  • oral
  • oropharynx
  • papillomavirus
  • prevalence
  • prevalence of HPV
  • public health
  • questionnaires
  • research
  • risk
  • risk factors
  • sequencing
  • target
  • universities
  • vaccination
  • vaccine
  • virology
  • wart
  • warts

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Authors

  • E M Smith

  • S Swarnavel

  • J M Ritchie

  • D Wang

  • T H Haugen

  • L P Turek

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