Preventing the second episode: A systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis

  • Álvarez-Jiménez M
  • Parker A
  • Hetrick S
 et al. 
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OBJECTIVE The majority of first-episode psychosis (FEP) patients reach clinical remission; however, rates of relapse are high. This study sought to undertake a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the effectiveness of pharmacological and non-pharmacological interventions to prevent relapse in FEP patients. METHODS Systematic review and meta-analysis of RCTs. RESULTS Of 66 studies retrieved, 18 were eligible for inclusion. Nine studies investigated psychosocial interventions and 9 pharmacological treatments. The analysis of 3 RCTs of psychosocial interventions comparing specialist FEP programs vs treatment as usual involving 679 patients demonstrated the former to be more effective in preventing relapse (odds ratio [OR]=1.80, 95% confidence interval [CI]=1.31-2.48; P

Author-supplied keywords

  • antipsychotic treatment
  • cognitive-behavioral therapy
  • first-episode psychosis
  • relapse prevention

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