Preventing the second episode: A systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis

  • Álvarez-Jiménez M
  • Parker A
  • Hetrick S
 et al. 
  • 161

    Readers

    Mendeley users who have this article in their library.
  • 83

    Citations

    Citations of this article.

Abstract

OBJECTIVE The majority of first-episode psychosis (FEP) patients reach clinical remission; however, rates of relapse are high. This study sought to undertake a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the effectiveness of pharmacological and non-pharmacological interventions to prevent relapse in FEP patients. METHODS Systematic review and meta-analysis of RCTs. RESULTS Of 66 studies retrieved, 18 were eligible for inclusion. Nine studies investigated psychosocial interventions and 9 pharmacological treatments. The analysis of 3 RCTs of psychosocial interventions comparing specialist FEP programs vs treatment as usual involving 679 patients demonstrated the former to be more effective in preventing relapse (odds ratio [OR]=1.80, 95% confidence interval [CI]=1.31-2.48; P

Author-supplied keywords

  • antipsychotic treatment
  • cognitive-behavioral therapy
  • first-episode psychosis
  • relapse prevention

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free