The Primary Cilium: A Signaling Center During Vertebrate Development

  • Grondona J
  • Granados-Durán P
  • Fernández-Llebrez P
 et al. 
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Abstract

The primary cilium has recently stepped into the spotlight, as a flood of data demonstrate that this organelle has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signaling pathways, possibly including the planar cell polarity pathway. The cilium therefore represents a nexus for signaling pathways during development. The connections between cilia and developmental signaling have begun to clarify the basis of human diseases associated with ciliary dysfunction.

Author-supplied keywords

  • 10
  • 1038
  • 1342-1353
  • 136
  • 2014
  • 24
  • acetylation
  • airway
  • atp-reactivation
  • axonemes
  • basal plate denudation
  • biotin-streptavidin
  • bovine trachea
  • caps
  • cell culture á
  • cell research
  • centrosome
  • cilia
  • cilia and flagella are
  • ciliary activity
  • ciliary membranes
  • ciliogenesis
  • colloidal-gold
  • communicating hydrocephalus
  • congenital hydrocephalus
  • cr
  • crowns
  • cyld
  • doi
  • ependymal cells á primary
  • ependymal defect
  • epithelium
  • flagella
  • foxj1
  • glia á rodents
  • hair-like cellular projections that
  • have a unique
  • heat shock protein
  • hsp
  • hsp70
  • hsp90
  • hyh
  • identified by antonie van
  • microtubule
  • microtubule assembly
  • microtubules
  • motile cilia
  • mouse
  • mucociliary escalator
  • multiciliated epithelium á dedifferentiation
  • of cell biology
  • pcm1
  • pericentriolar satellites
  • place in the history
  • primary cilium
  • published online 24 october
  • reissner fiber
  • rfx
  • subcommissural organ
  • tcp-1
  • trachea
  • transcriptional regulation
  • tubulin
  • ubiquitination
  • ventricular wall á radial
  • á

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Authors

  • J M Grondona

  • P. Granados-Durán

  • P. Fernández-Llebrez

  • M. D. López-Ávalos

  • M T Ome

  • Ralph M Steinman

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