Production and clinical application of [15O]-labelled gasses Positron Emission Tomography (PET) is used for in vivo measurement of physiological processes, both qualitatively and quantitatively. 15O is a radionuclide that is regularly used in PET. Next to its use in [15O]H2 O, it is also used as a radioactive gas. [ 15O]O2 , [15O]CO and [15O]CO2 are inhaled for use in both cardiology and neurology for determining oxygen metabolism, blood volume and cerebral perfusion. [15O]-gasses have a very short half-life of about 2 minutes, which makes validation of the production process, rapid synthesis and rapid analysis inevitable. This requires extensive logistics and the use of an on-site cyclotron.
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