Profiling pH changes in the electrospray plume

  • Zhou S
  • Prebyl B
  • Cook K
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Laser-induced fluorescence spectrometry is used to profile pH changes as droplets evap. in an electrospray plume by measuring emission spectra of 2(or 4)[10-(dimethylamino)-3-oxo-3H-benzo[c]xanthene-7-yl]-benzenedicarboxylic acid (carboxy SNARF-1), a pH-sensitive fluorescent dye. The obsd. pH changes depend on initial droplet pH and polarity. In some instances, small or negligible changes of pH are obsd., consistent with expected buffering. The pH of initially acidic droplets decreases along the spray axis in both pos. and neg. ion modes, to an extent larger than expected from solvent evapn. This phenomenon may be a manifestation of droplet cooling, droplet subdivision, or heterogeneous charge distribution within the spray plume or within individual ES droplets. [on SciFinder(R)]

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  • Shaolian Zhou

  • Benjamin S. Prebyl

  • Kelsey D. Cook

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