The dogma that the genesis of cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of (central nervous system) CNS tumors. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogene- sis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.
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